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Indications:
Coenzyme A (metabolite of dexpanthenol) is important for deep penetrating moisturizer; stimulates epithelization; has wound healing effect; has an anti-inflammatory effect.
Only the D-Panthenol is the provitamin of D-Pantothenic acid (vitamin B5), not the L-Panthenol.
A cream with dexpanthenol regularly applied to the skin improves the moisture content of dry skin significantly.
A cream with 5% dexpanthenol accelerates the healing of superficial wounds by approximately 30%.
An ointment with dexpanthenol prevents erythema due to UV light.
Dexpanthenol ointment also protects the lips against solar herpes, Sun burns, mild burns, skin irritations, dry or cracked skin, cosmetic or shaving rashes, post chemical peeling treatment, post laser resurfacing treatment ( 11th -15th day).
Dexpanthenol is effective for preventing / treating nappy dermatitis in infants.
Usual Dose:
Apply twice daily to the affected areas. If accidentally applied to eyes or sensitive area, wash thoroughly with warm water.
Mechanism Of Action:
D-Panthenol is the provitamin of D-Pantothenic acid (Vitamin B).D-Pantothenic acid plays a key role in the human intermediary metabolism. It is a part of the Coenzyme A. Deficiency of Vitamin B5 results in many dermatological disorders. In man, topical dextropantothenyl alcohol has been reported to influence the course of various ulcerative and pyogenic dermatoses by allaying and calming itching and by stimulating epithelization…
Dextropanthenyl alcohol has been used topically in the treatment of burns, wounds decubitus ulcers, eczema, contact dermatitis and pruritus. It is also used to prevent / treat dry desquamating lesions, which respond more easily than exudative lesions. Dexpanthenol is also used in treatment of lupus erythematosus.
Pharmacokinetics:
Topically applied Dexpanthenol is absorbed by the skin and is rapidly transformed into Pantothenic in vivo, which may be distributed throughout the body, primarily as coenzyme A.
Precautions and Contraindications:
In case of observation of hypersensitivity to any ingredient of the product the treatment should be discontinued.Topical preparations of dexpanthenol should not be used as dietary supplement.
Pregnancy –It can be used safely.
Breast-feeding- It can be used safely.
Geriatrics- It can be used safely.
Pediatrics- It can be used safely.
Adverse Reactions:
Stop taking your medicine right away and talk to your doctor if you observe the following side effects. Your medicine may cause these symptoms which may mean you are allergic to it:
-Skin hives, rash, or itchy or swollen skin.
At application under indications and in recommended doses no side effects were observed.
Drug Interactions:
Dextropanthenyl alcohol in combination with hydrocortisone may be more effective than topical hydrocortisone alone in some dermatoses.
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