Biperiden | Caspian Tamin Pharmaceutical Company

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Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as biperiden is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum, which then restores the balance.

The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden , these drug-induced disturbances are rapidly brought under control. Subsequently, this can usually be maintained with oral doses which may be given with tranquilizer therapy in psychotic and other conditions requiring an uninterrupted therapeutic program.

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The metabolism of biperiden is also incompletely understood, but does involve hydroxylation. In normal volunteers a single 10 mg intravenous dose of biperiden seemed to cause a transient rise in plasma cortisol and prolactin. No change in GH, LH, FSH, or TSH levels were seen. Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when injected intramuscularly (1.0 mL) into the sacrospinalis muscles and intradermally (0.25 mL) and subcutaneously (0.5 mL) into the shaved abdominal skin.

[view] =>

The metabolism of biperiden is also incompletely understood, but does involve hydroxylation. In normal volunteers a single 10 mg intravenous dose of biperiden seemed to cause a transient rise in plasma cortisol and prolactin. No change in GH, LH, FSH, or TSH levels were seen. Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when injected intramuscularly (1.0 mL) into the sacrospinalis muscles and intradermally (0.25 mL) and subcutaneously (0.5 mL) into the shaved abdominal skin.

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CNS Effects:
Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior).
Use with caution in patients with epilepsy.

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Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden. Use with caution in patients with glaucoma.

Cardiovascular Effects:
Possible tachycardia; use with caution in patients with cardiac arrhythmias.

GU Effects:
Possible urinary retention; use with caution in patients with prostatic hypertrophy.

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CNS Effects:
Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior).
Use with caution in patients with epilepsy.

Ophthalmic Effects:
Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden. Use with caution in patients with glaucoma.

Cardiovascular Effects:
Possible tachycardia; use with caution in patients with cardiac arrhythmias.

GU Effects:
Possible urinary retention; use with caution in patients with prostatic hypertrophy.

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Agitation; blurred vision; constipation; dizziness or lightheadedness when sitting up or standing; drowsiness; dry mouth, nose, or throat; nausea; nervousness; stomach upset.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; chest pain; confusion; disorientation; exaggerated sense of well-being; fast, slow, or irregular heartbeat; flushing; hallucinations; loss of coordination; memory loss; mood or mental changes; seizures; trouble urinating.

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Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as biperiden is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum, which then restores the balance.

The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden , these drug-induced disturbances are rapidly brought under control. Subsequently, this can usually be maintained with oral doses which may be given with tranquilizer therapy in psychotic and other conditions requiring an uninterrupted therapeutic program.

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The metabolism of biperiden is also incompletely understood, but does involve hydroxylation. In normal volunteers a single 10 mg intravenous dose of biperiden seemed to cause a transient rise in plasma cortisol and prolactin. No change in GH, LH, FSH, or TSH levels were seen. Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when injected intramuscularly (1.0 mL) into the sacrospinalis muscles and intradermally (0.25 mL) and subcutaneously (0.5 mL) into the shaved abdominal skin.

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The metabolism of biperiden is also incompletely understood, but does involve hydroxylation. In normal volunteers a single 10 mg intravenous dose of biperiden seemed to cause a transient rise in plasma cortisol and prolactin. No change in GH, LH, FSH, or TSH levels were seen. Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when injected intramuscularly (1.0 mL) into the sacrospinalis muscles and intradermally (0.25 mL) and subcutaneously (0.5 mL) into the shaved abdominal skin.

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The metabolism of biperiden is also incompletely understood, but does involve hydroxylation. In normal volunteers a single 10 mg intravenous dose of biperiden seemed to cause a transient rise in plasma cortisol and prolactin. No change in GH, LH, FSH, or TSH levels were seen. Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when injected intramuscularly (1.0 mL) into the sacrospinalis muscles and intradermally (0.25 mL) and subcutaneously (0.5 mL) into the shaved abdominal skin.

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The metabolism of biperiden is also incompletely understood, but does involve hydroxylation. In normal volunteers a single 10 mg intravenous dose of biperiden seemed to cause a transient rise in plasma cortisol and prolactin. No change in GH, LH, FSH, or TSH levels were seen. Biperiden lactate (10 mg/mL) was not irritating to the tissue of rabbits when injected intramuscularly (1.0 mL) into the sacrospinalis muscles and intradermally (0.25 mL) and subcutaneously (0.5 mL) into the shaved abdominal skin.

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Treating Parkinson disease and other Parkinson-like disorders. It is used to treat certain side effects (eg, involuntary movements) caused by certain medicines. It may also be used for other conditions as determined by your doctor.

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Treating Parkinson disease and other Parkinson-like disorders. It is used to treat certain side effects (eg, involuntary movements) caused by certain medicines. It may also be used for other conditions as determined by your doctor.

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Treating Parkinson disease and other Parkinson-like disorders. It is used to treat certain side effects (eg, involuntary movements) caused by certain medicines. It may also be used for other conditions as determined by your doctor.

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Treating Parkinson disease and other Parkinson-like disorders. It is used to treat certain side effects (eg, involuntary movements) caused by certain medicines. It may also be used for other conditions as determined by your doctor.

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• Narrow angle glaucoma.
• Bowel obstruction or megacolon.
• Known hypersensitivity to biperiden or any ingredient in the formulation.

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• Narrow angle glaucoma.
• Bowel obstruction or megacolon.
• Known hypersensitivity to biperiden or any ingredient in the formulation.

) [#title] => [#description] => [#children] =>

• Narrow angle glaucoma.
• Bowel obstruction or megacolon.
• Known hypersensitivity to biperiden or any ingredient in the formulation.

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• Narrow angle glaucoma.
• Bowel obstruction or megacolon.
• Known hypersensitivity to biperiden or any ingredient in the formulation.

[#printed] => 1 ) [#title] => [#description] => [#children] => [#printed] => 1 ) [field_precautions] => Array ( [#type_name] => product [#context] => full [#field_name] => field_precautions [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 8 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_precautions [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => CNS Effects: Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior). Use with caution in patients with epilepsy. Ophthalmic Effects: Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden. Use with caution in patients with glaucoma. Cardiovascular Effects: Possible tachycardia; use with caution in patients with cardiac arrhythmias. GU Effects: Possible urinary retention; use with caution in patients with prostatic hypertrophy. [format] => 1 [safe] =>

CNS Effects:
Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior).
Use with caution in patients with epilepsy.

Ophthalmic Effects:
Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden. Use with caution in patients with glaucoma.

Cardiovascular Effects:
Possible tachycardia; use with caution in patients with cardiac arrhythmias.

GU Effects:
Possible urinary retention; use with caution in patients with prostatic hypertrophy.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

CNS Effects:
Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior).
Use with caution in patients with epilepsy.

Ophthalmic Effects:
Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden. Use with caution in patients with glaucoma.

Cardiovascular Effects:
Possible tachycardia; use with caution in patients with cardiac arrhythmias.

GU Effects:
Possible urinary retention; use with caution in patients with prostatic hypertrophy.

) [#title] => [#description] => [#children] =>

CNS Effects:
Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior).
Use with caution in patients with epilepsy.

Ophthalmic Effects:
Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden. Use with caution in patients with glaucoma.

Cardiovascular Effects:
Possible tachycardia; use with caution in patients with cardiac arrhythmias.

GU Effects:
Possible urinary retention; use with caution in patients with prostatic hypertrophy.

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CNS Effects:
Large or toxic doses or usual doses in patients with excess susceptibility may produce marked CNS disturbances (e.g., mental confusion, euphoria, agitation, disturbed behavior).
Use with caution in patients with epilepsy.

Ophthalmic Effects:
Increased ocular tension associated with antimuscarinic use; however, such effect not reported with biperiden. Use with caution in patients with glaucoma.

Cardiovascular Effects:
Possible tachycardia; use with caution in patients with cardiac arrhythmias.

GU Effects:
Possible urinary retention; use with caution in patients with prostatic hypertrophy.

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Alcohol:
Possible additive CNS effects

Anticholinergic agents:
Increased risk of adverse anticholinergic effects

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Alcohol:
Possible additive CNS effects

Anticholinergic agents:
Increased risk of adverse anticholinergic effects

) [#title] => [#description] => [#children] =>

Alcohol:
Possible additive CNS effects

Anticholinergic agents:
Increased risk of adverse anticholinergic effects

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Alcohol:
Possible additive CNS effects

Anticholinergic agents:
Increased risk of adverse anticholinergic effects

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Agitation; blurred vision; constipation; dizziness or lightheadedness when sitting up or standing; drowsiness; dry mouth, nose, or throat; nausea; nervousness; stomach upset.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; chest pain; confusion; disorientation; exaggerated sense of well-being; fast, slow, or irregular heartbeat; flushing; hallucinations; loss of coordination; memory loss; mood or mental changes; seizures; trouble urinating.

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Agitation; blurred vision; constipation; dizziness or lightheadedness when sitting up or standing; drowsiness; dry mouth, nose, or throat; nausea; nervousness; stomach upset.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; chest pain; confusion; disorientation; exaggerated sense of well-being; fast, slow, or irregular heartbeat; flushing; hallucinations; loss of coordination; memory loss; mood or mental changes; seizures; trouble urinating.

) [#title] => [#description] => [#children] =>

Agitation; blurred vision; constipation; dizziness or lightheadedness when sitting up or standing; drowsiness; dry mouth, nose, or throat; nausea; nervousness; stomach upset.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; chest pain; confusion; disorientation; exaggerated sense of well-being; fast, slow, or irregular heartbeat; flushing; hallucinations; loss of coordination; memory loss; mood or mental changes; seizures; trouble urinating.

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Agitation; blurred vision; constipation; dizziness or lightheadedness when sitting up or standing; drowsiness; dry mouth, nose, or throat; nausea; nervousness; stomach upset.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); anxiety; behavior changes; chest pain; confusion; disorientation; exaggerated sense of well-being; fast, slow, or irregular heartbeat; flushing; hallucinations; loss of coordination; memory loss; mood or mental changes; seizures; trouble urinating.

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• Store below 30 C°
• Protect from light and freezing

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

) [#title] => [#description] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

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• Store below 30 C°
• Protect from light and freezing

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• Injection 5mg/1ml: Box of 10Ampoules

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• Injection 5mg/1ml: Box of 10Ampoules

) [#title] => [#description] => [#children] =>

• Injection 5mg/1ml: Box of 10Ampoules

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• Injection 5mg/1ml: Box of 10Ampoules

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Biperiden is a weak peripheral anticholinergic agent. It has, therefore, some antisecretory, antispasmodic and mydriatic effects. In addition, biperiden possesses nicotinolytic activity. Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as biperiden is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum, which then restores the balance.

The parenteral form of biperiden is an effective and reliable agent for the treatment of acute episodes of extrapyramidal disturbances sometimes seen during treatment with neuroleptic agents. Akathisia, akinesia, dyskinetic tremors, rigor, oculogyric crisis, spasmodic torticollis, and profuse sweating are markedly reduced or eliminated. With parenteral biperiden , these drug-induced disturbances are rapidly brought under control. Subsequently, this can usually be maintained with oral doses which may be given with tranquilizer therapy in psychotic and other conditions requiring an uninterrupted therapeutic program.

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