Diazepam

Generic Name: Diazepam
Brand Name: ZEPADIC®
Dosage Form: Injection 10mg/2ml
Pharmacological Category: Benzodiazepines
Therapeutic Category: Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic
Pregnancy Category: Category D

Pharmacology

facilitation of the action of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system.

Pharmacokinetics:

Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

Indications:

treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

Contraindications:

Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

Precautions:

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

Drug Interactions:

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

Side Effects:

• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

Storage:

• Store below 30 C°
• Protect from light and freezing

Packing:

• Injection 10mg/2ml: Box of 10,100 Ampoules

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Image: 
Brand Name: 

ZEPADIC®

Dosage Form: 

Injection 10mg/2ml

Pharmacological Category: 

Benzodiazepines

Therapeutic Category: 

Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic

Pregnancy Category: 

Category D

facilitation of the action of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system.

Pharmacokinetics: 

Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

Indications: 

treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

Contraindications: 

Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

Precautions: 

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

Drug Interactions: 

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

Side Effects: 

• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

Storage: 

• Store below 30 C°
• Protect from light and freezing

Packing: 

• Injection 10mg/2ml: Box of 10,100 Ampoules

PDF: 
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ZEPADIC®

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Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

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Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

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• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

[view] =>

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

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treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

[view] =>

treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

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• Injection 10mg/2ml: Box of 10,100 Ampoules

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Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

[view] =>

Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

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Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

[view] =>

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

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Category D

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• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

[view] =>

• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

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• Protect from light and freezing

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• Protect from light and freezing

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Pharmacological Category: 

Benzodiazepines

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Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic

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Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic

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Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic

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Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic

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Therapeutic Category: 

Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic

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Category D

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Category D

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Category D

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Category D

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Pregnancy Category: 

Category D

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facilitation of the action of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system.

[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Absorption: Apparently well absorbed following oral administration. Absorption is slow and erratic following IM administration. Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children. Onset Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration. Duration Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration. Distribution: Apparently widely distributed into body tissues; crosses the blood-brain barrier. Diazepam and its metabolites cross the placenta and are distributed into milk. Plasma Protein Binding: Diazepam and desmethyldiazepam: 95–98%. Elimination: Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites. Excreted principally in urine as inactive conjugates. Half-life: Diazepam: 20–50 hours. Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours. [format] => 1 [safe] =>

Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

) [#title] => [#description] => [#children] =>

Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

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Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Pharmacokinetics: 

Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

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treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

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treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

) [#title] => [#description] => [#children] =>

treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

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treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Indications: 

treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

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Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

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Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

) [#title] => [#description] => [#children] =>

Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

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Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Contraindications: 

Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

[#printed] => 1 ) [field_precautions] => Array ( [#type_name] => product [#context] => full [#field_name] => field_precautions [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 8 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_precautions [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients. [format] => 1 [safe] =>

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

) [#title] => [#description] => [#children] =>

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_precautions [#title] => Precautions [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Precautions: 

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

[#printed] => 1 ) [field_drug_interactions] => Array ( [#type_name] => product [#context] => full [#field_name] => field_drug_interactions [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 9 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_drug_interactions [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => • cimetidine; • omeprazole; • phenytoin; • an antibiotic--clarithromycin, erythromycin, telithromycin; • an antidepressant such as fluoxetine, fluoxetine, and others; • antifungal medicine--itraconazole, ketoconazole, voriconazole; • heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or • HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir. [format] => 1 [safe] =>

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

) [#title] => [#description] => [#children] =>

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_drug_interactions [#title] => Drug Interactions [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Drug Interactions: 

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

[#printed] => 1 ) [field_side_effects] => Array ( [#type_name] => product [#context] => full [#field_name] => field_side_effects [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 10 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_side_effects [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => • confusion, hallucinations, unusual thoughts or behavior; • unusual risk-taking behavior, decreased inhibitions, no fear of danger; • depressed mood, thoughts of suicide or hurting yourself; • hyperactivity, agitation, aggression, hostility; • new or worsening seizures; • weak or shallow breathing; • a feeling like you might pass out; • muscle twitching, tremor; • loss of bladder control; or • little or no urinating. Common diazepam side effects may include: • memory problems; • drowsiness, tired feeling; • dizziness, spinning sensation; • feeling restless or irritable; • muscle weakness; • nausea, constipation; • drooling or dry mouth, slurred speech; • blurred vision, double vision; • mild skin rash, itching; or • loss of interest in sex. [format] => 1 [safe] =>

• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

) [#title] => [#description] => [#children] =>

• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

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• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Side Effects: 

• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

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• Store below 30 C°
• Protect from light and freezing

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

) [#title] => [#description] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_storage [#title] => Storage [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

• Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Storage: 

• Store below 30 C°
• Protect from light and freezing

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• Injection 10mg/2ml: Box of 10,100 Ampoules

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Injection 10mg/2ml: Box of 10,100 Ampoules

) [#title] => [#description] => [#children] =>

• Injection 10mg/2ml: Box of 10,100 Ampoules

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• Injection 10mg/2ml: Box of 10,100 Ampoules

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Packing: 

• Injection 10mg/2ml: Box of 10,100 Ampoules

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PDF: 
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Image: 
Brand Name: 

ZEPADIC®

Dosage Form: 

Injection 10mg/2ml

Pharmacological Category: 

Benzodiazepines

Therapeutic Category: 

Anxiolytic,Sedative,Hypnotic Anticonvulsant and Antipsychotic

Pregnancy Category: 

Category D

facilitation of the action of gamma aminobutyric acid (GABA), an inhibitory neurotransmitter in the central nervous system.

Pharmacokinetics: 

Absorption:
Apparently well absorbed following oral administration.
Absorption is slow and erratic following IM administration.
Rapidly and well absorbed following rectal administration as gel or solution; bioavailability averages 80–102%. Peak plasma concentrations attained within 1.5 hours following rectal administration of the gel in adults; absorption from gel may be more rapid in children.

Onset
Onset of anticonvulsant, anxiolytic, or sedative action occurs in 1–5 minutes following IV administration.

Duration
Duration of anticonvulsant, anxiolytic, or sedative action is 15–60 minutes following IV administration.

Distribution:
Apparently widely distributed into body tissues; crosses the blood-brain barrier.
Diazepam and its metabolites cross the placenta and are distributed into milk.
Plasma Protein Binding:
Diazepam and desmethyldiazepam: 95–98%.

Elimination:
Metabolized in the liver by CYP2C19 and CYP3A4 to active metabolites.
Excreted principally in urine as inactive conjugates.

Half-life:
Diazepam: 20–50 hours.
Metabolites: Desmethyldiazepam: 30–200 hours. Temazepam: 5–20 hours. Oxazepam: 3–21 hours.

Indications: 

treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Diazepam is sometimes used with other medications to treat seizures.

Contraindications: 

Diazepam is contraindicated in patients with a known hypersensitivity to this drug; acute narrow angle glaucoma; and open angle glaucoma unless patients are receiving appropriate therapy.

Precautions: 

Although seizures may be brought under control promptly, a significant proportion of patients experience a return to seizure activity, presumably due to the short-lived effect of diazepam after I.V. administration. The physician should be prepared to re-administer the drug. However, diazepam is not recommended for maintenance, and once seizures are brought under control, consideration should be given to the administration of agents useful in longer term control of seizures. Diazepam Injection has produced hypotension or muscular weakness in some patients particularly when used with narcotics, barbiturates or alcohol. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients.

Drug Interactions: 

• cimetidine;
• omeprazole;
• phenytoin;
• an antibiotic--clarithromycin, erythromycin, telithromycin;
• an antidepressant such as fluoxetine, fluoxetine, and others;
• antifungal medicine--itraconazole, ketoconazole, voriconazole;
• heart or blood pressure medication such as diltiazem, nicardipine, quinidine, verapamil, and others; or
• HIV/AIDS medicine--atazanavir, delavirdine, fosamprenavir, indinavir, nelfinavir, saquinavir, or ritonavir.

Side Effects: 

• confusion, hallucinations, unusual thoughts or behavior;
• unusual risk-taking behavior, decreased inhibitions, no fear of danger;
• depressed mood, thoughts of suicide or hurting yourself;
• hyperactivity, agitation, aggression, hostility;
• new or worsening seizures;
• weak or shallow breathing;
• a feeling like you might pass out;
• muscle twitching, tremor;
• loss of bladder control; or
• little or no urinating.

Common diazepam side effects may include:
• memory problems;
• drowsiness, tired feeling;
• dizziness, spinning sensation;
• feeling restless or irritable;
• muscle weakness;
• nausea, constipation;
• drooling or dry mouth, slurred speech;
• blurred vision, double vision;
• mild skin rash, itching; or
• loss of interest in sex.

Storage: 

• Store below 30 C°
• Protect from light and freezing

Packing: 

• Injection 10mg/2ml: Box of 10,100 Ampoules

PDF: 
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CONTACT US:

Head Office:
Address: No.1, Beastoon Ave., Dr. Fatemi Sq., Tehran1431663135 Iran
Tel: (+98 21)-889 65323
Fax: (+98 21)-889 57056
Factory:
Address: Caspian tamin Pharmaceutical Co., Entrance 1, Rasht Industrial Zone, Rasht, Guilan, Iran
Tel: (+98 131) 338-2511- 8
Fax: (+98 131) 338 – 2517