Ibuprofen

Generic Name: Ibuprofen
Brand Name: -
Dosage Form:
Pharmacological Category: Non-steroidal Anti-inflammatory agents
Therapeutic Category: Analgesic, Antipyretic
Pregnancy Category: Category C

Pharmacology

Ibuprofen's mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition

Pharmacokinetics:

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

Indications:

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

Contraindications:

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

Precautions:

Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

Drug Interactions:

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

Side Effects:

Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,

Storage:

• Store below 30 C°
• Protect from light and freezing

Packing:

• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

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Image: 
Brand Name: 

-

Pharmacological Category: 

Non-steroidal Anti-inflammatory agents

Therapeutic Category: 

Analgesic, Antipyretic

Pregnancy Category: 

Category C

Ibuprofen's mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition

Pharmacokinetics: 

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

Indications: 

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

Contraindications: 

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

Precautions: 

Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

Drug Interactions: 

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

Side Effects: 

Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,

Storage: 

• Store below 30 C°
• Protect from light and freezing

Packing: 

• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

PDF: 
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Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen


Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients


Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

[format] => 1 [safe] =>

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

[view] =>

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

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Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,


Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.


Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.


Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

[format] => 1 [safe] =>

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

[view] =>

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

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Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.


Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

[format] => 1 [safe] =>

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

[view] =>

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

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• Injection 800mg/8ml: boxes of 5 Ampoules

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• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

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Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

[view] =>

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

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Non-steroidal Anti-inflammatory agents

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Non-steroidal Anti-inflammatory agents

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Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

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Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

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Category C

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• Protect from light and freezing

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Category C

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Category C

) [#title] => [#description] => [#children] =>

Category C

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pregnancy_category [#title] => Pregnancy Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Category C

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Pregnancy Category: 

Category C

[#printed] => 1 ) [body] => Array ( [#weight] => 3 [#value] =>

Ibuprofen's mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition

[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug. [format] => 1 [safe] =>

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

) [#title] => [#description] => [#children] =>

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pharmacokinetics [#title] => Pharmacokinetics [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Pharmacokinetics: 

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

[#printed] => 1 ) [field_indications] => Array ( [#type_name] => product [#context] => full [#field_name] => field_indications [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 5 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_indications [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] =>

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.


Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

[format] => 1 [safe] =>

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

) [#title] => [#description] => [#children] =>

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_indications [#title] => Indications [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Indications: 

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

[#printed] => 1 ) [field_administration_and_dosage] => Array ( [#type_name] => product [#context] => full [#field_name] => field_administration_and_dosage [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 6 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_administration_and_dosage [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => [format] => [safe] => [#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => ) [#title] => [#description] => [#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_administration_and_dosage [#title] => Administration and Dosage [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#printed] => 1 ) [#title] => [#description] => [#printed] => 1 ) [field_contraindications] => Array ( [#type_name] => product [#context] => full [#field_name] => field_contraindications [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 7 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_contraindications [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] =>

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen


Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients


Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

[format] => 1 [safe] =>

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

) [#title] => [#description] => [#children] =>

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_contraindications [#title] => Contraindications [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Contraindications: 

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

[#printed] => 1 ) [field_precautions] => Array ( [#type_name] => product [#context] => full [#field_name] => field_precautions [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 8 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_precautions [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis [format] => 1 [safe] =>

Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

) [#title] => [#description] => [#children] =>

Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_precautions [#title] => Precautions [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Precautions: 

Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

[#printed] => 1 ) [field_drug_interactions] => Array ( [#type_name] => product [#context] => full [#field_name] => field_drug_interactions [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 9 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_drug_interactions [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] =>

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,


Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.


Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.


Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

[format] => 1 [safe] =>

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

) [#title] => [#description] => [#children] =>

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_drug_interactions [#title] => Drug Interactions [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Drug Interactions: 

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

[#printed] => 1 ) [field_side_effects] => Array ( [#type_name] => product [#context] => full [#field_name] => field_side_effects [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 10 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_side_effects [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions, [format] => 1 [safe] =>

Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,

) [#title] => [#description] => [#children] =>

Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_side_effects [#title] => Side Effects [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Side Effects: 

Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,

[#printed] => 1 ) [field_storage] => Array ( [#type_name] => product [#context] => full [#field_name] => field_storage [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 11 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_storage [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => • Store below 30 C° • Protect from light and freezing [format] => 1 [safe] =>

• Store below 30 C°
• Protect from light and freezing

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

) [#title] => [#description] => [#children] =>

• Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_storage [#title] => Storage [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

• Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [#title] => [#description] => [#children] =>
Storage: 

• Store below 30 C°
• Protect from light and freezing

[#printed] => 1 ) [field_packing] => Array ( [#type_name] => product [#context] => full [#field_name] => field_packing [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 12 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_packing [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => • Injection 400mg/4ml: boxes of 5 Ampoules • Injection 800mg/8ml: boxes of 5 Ampoules [format] => 1 [safe] =>

• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

) [#title] => [#description] => [#children] =>

• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

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• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

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• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

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Image: 
Brand Name: 

-

Pharmacological Category: 

Non-steroidal Anti-inflammatory agents

Therapeutic Category: 

Analgesic, Antipyretic

Pregnancy Category: 

Category C

Ibuprofen's mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition

Pharmacokinetics: 

Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.

Indications: 

Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.

Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.

Contraindications: 

Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen

Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients

Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery

Precautions: 

Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis

Drug Interactions: 

Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,

Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.

Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.

Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.

Side Effects: 

Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,

Storage: 

• Store below 30 C°
• Protect from light and freezing

Packing: 

• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules

PDF: 
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CONTACT US:

Head Office:
Address: No.1, Beastoon Ave., Dr. Fatemi Sq., Tehran1431663135 Iran
Tel: (+98 21)-889 65323
Fax: (+98 21)-889 57056
Factory:
Address: Caspian tamin Pharmaceutical Co., Entrance 1, Rasht Industrial Zone, Rasht, Guilan, Iran
Tel: (+98 131) 338-2511- 8
Fax: (+98 131) 338 – 2517