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Pethidin
Generic Name: Pethidin
Brand Name: -
Dosage Form: Injection 100mg/2ml - Injection 50mg/1m
Pharmacological Category: Analgesic, adjunct to anesthesia
Therapeutic Category: Analgesic
Pregnancy Category: category B
Pharmacology
Binds to and depresses opiate receptors in spinal cord and CNS, altering perception of and response to pain
Pharmacokinetics:
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Indications:
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
Contraindications:
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
Precautions:
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Drug Interactions:
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
Side Effects:
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
Storage:
• Store below 30 C°
• Protect from light and freezing
Packing:
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
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Image:
Brand Name:
-
Dosage Form:
Injection 100mg/2ml - Injection 50mg/1m
Pharmacological Category:
Analgesic, adjunct to anesthesia
Therapeutic Category:
Analgesic
Pregnancy Category:
category B
Binds to and depresses opiate receptors in spinal cord and CNS, altering perception of and response to pain
Pharmacokinetics:
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Indications:
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
Contraindications:
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
Precautions:
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Drug Interactions:
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
Side Effects:
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
Storage:
• Store below 30 C°
• Protect from light and freezing
Packing:
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
PDF:
)
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• MAO inhibitor use within past 14 days
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
Injection 100mg/2ml - Injection 50mg/1m
[view] =>Injection 100mg/2ml - Injection 50mg/1m
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Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Analgesic, adjunct to anesthesia
[view] =>Analgesic, adjunct to anesthesia
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• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
category B
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CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Analgesic
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-
Injection 100mg/2ml - Injection 50mg/1m
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Dosage Form:
Injection 100mg/2ml - Injection 50mg/1m
Analgesic, adjunct to anesthesia
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Pharmacological Category:
Analgesic, adjunct to anesthesia
Analgesic
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Analgesic
category B
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Pregnancy Category:
category B
Binds to and depresses opiate receptors in spinal cord and CNS, altering perception of and response to pain
[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Route Onset Peak Duration IM, SC 10–15 min 30–60 min 2–4 hr IV Immediate 5–7 min 2–4 hr Metabolism: Hepatic; T1/2: 3–8 hr Distribution: Crosses placenta; enters breast milk Excretion: Urine [format] => 1 [safe] =>Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Pharmacokinetics:
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
Indications:
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
Contraindications:
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Precautions:
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
Drug Interactions:
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
Side Effects:
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Storage:
• Store below 30 C°
• Protect from light and freezing
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
Packing:
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
PDF:
Image:
Brand Name:
-
Dosage Form:
Injection 100mg/2ml - Injection 50mg/1m
Pharmacological Category:
Analgesic, adjunct to anesthesia
Therapeutic Category:
Analgesic
Pregnancy Category:
category B
Binds to and depresses opiate receptors in spinal cord and CNS, altering perception of and response to pain
Pharmacokinetics:
Route Onset Peak Duration
IM, SC 10–15 min 30–60 min 2–4 hr
IV Immediate 5–7 min 2–4 hr
Metabolism: Hepatic; T1/2: 3–8 hr
Distribution: Crosses placenta; enters breast milk
Excretion: Urine
Indications:
• Moderate to severe pain
• Preoperative sedation
• Analgesia during labor
Contraindications:
• Hypersensitivity to drug or bisulfites (with some injectable products)
• MAO inhibitor use within past 14 days
Precautions:
Use cautiously in:
• head trauma; increased intracranial pressure (ICP); severe renal, hepatic, or pulmonary disease; hypothyroidism; adrenal insufficiency; extensive burns; alcoholism
• undiagnosed abdominal pain or prostatic hyperplasia
• elderly or debilitated patients
• pregnant patients (not recommended before labor)
• labor (drug may cause respiratory depression in neonate)
• breastfeeding patients
• children.
Drug Interactions:
Antihistamines, sedative-hypnotics: additive CNS depression
Barbiturates, cimetidine, protease inhibitor antiretrovirals: increased respiratory and CNS depression
Chlorpromazine, thioridazine: increased risk of pethedine toxicity
MAO inhibitors, procarbazine: potentially fatal reaction
Opioid agonist-antagonists: precipitation of opioid withdrawal in physically dependent patients
Phenytoin: increased meperidine metabolism and decreased effects
Side Effects:
CNS: confusion, sedation, dysphoria, euphoria, floating feeling, hallucinations, headache, unusual dreams, seizures
CV: hypotension, bradycardia, cardiac arrest, shock
EENT: blurred vision, diplopia, miosis
GI: nausea, vomiting, constipation, ileus, biliary tract spasms
GU: urinary retention
Respiratory: respiratory depression, respiratory arrest
Skin: flushing, sweating, induration
Other: pain at injection site, local irritation, physical or psychological drug dependence, drug tolerance
Storage:
• Store below 30 C°
• Protect from light and freezing
Packing:
• Pethidine Injection 50mg / 1ml : 10 ampoules/box
• Pethidine Injection 100mg / 2ml : 10 ampoules/box
PDF: