Ibuprofen's mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition
Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,
• Store below 30 C°
• Protect from light and freezing
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
-
Non-steroidal Anti-inflammatory agents
Analgesic, Antipyretic
Category C
Ibuprofen's mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition
Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,
• Store below 30 C°
• Protect from light and freezing
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
-
[view] =>-
) ) [field_contraindications] => Array ( [0] => Array ( [value] =>Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
[view] =>Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
) ) [field_pharmacological_category] => Array ( [0] => Array ( [value] => Non-steroidal Anti-inflammatory agents [format] => 1 [safe] =>Non-steroidal Anti-inflammatory agents
[view] =>Non-steroidal Anti-inflammatory agents
) ) [field_precautions] => Array ( [0] => Array ( [value] => Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis [format] => 1 [safe] =>Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis
[view] =>Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis
) ) [field_pregnancy_category] => Array ( [0] => Array ( [value] => Category C [format] => 1 [safe] =>Category C
[view] =>Category C
) ) [field_references] => Array ( [0] => Array ( [value] => [format] => [safe] => [view] => ) ) [field_side_effects] => Array ( [0] => Array ( [value] => Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions, [format] => 1 [safe] =>Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,
[view] =>Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,
) ) [field_storage] => Array ( [0] => Array ( [value] => • Store below 30 C° • Protect from light and freezing [format] => 1 [safe] =>• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
Analgesic, Antipyretic
[view] =>Analgesic, Antipyretic
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[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>-
) [#title] => [#description] => [#children] =>-
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_brand_name [#title] => Brand Name [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>-
[#printed] => 1 ) [#title] => [#description] => [#children] =>-
Non-steroidal Anti-inflammatory agents
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Non-steroidal Anti-inflammatory agents
) [#title] => [#description] => [#children] =>Non-steroidal Anti-inflammatory agents
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pharmacological_category [#title] => Pharmacological Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Non-steroidal Anti-inflammatory agents
[#printed] => 1 ) [#title] => [#description] => [#children] =>Non-steroidal Anti-inflammatory agents
Analgesic, Antipyretic
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Analgesic, Antipyretic
) [#title] => [#description] => [#children] =>Analgesic, Antipyretic
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_therapeutic_category [#title] => Therapeutic Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Analgesic, Antipyretic
[#printed] => 1 ) [#title] => [#description] => [#children] =>Analgesic, Antipyretic
Category C
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Category C
) [#title] => [#description] => [#children] =>Category C
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pregnancy_category [#title] => Pregnancy Category [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Category C
[#printed] => 1 ) [#title] => [#description] => [#children] =>Category C
Ibuprofen's mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition
[#title] => [#description] => [#printed] => 1 ) [field_pharmacokinetics] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pharmacokinetics [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 4 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pharmacokinetics [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug. [format] => 1 [safe] =>Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
) [#title] => [#description] => [#children] =>Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pharmacokinetics [#title] => Pharmacokinetics [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
[#printed] => 1 ) [#title] => [#description] => [#children] =>Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis
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[#printed] => 1 ) [#title] => [#description] => [#children] =>Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,
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) [#title] => [#description] => [#children] =>Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,
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• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Store below 30 C°
• Protect from light and freezing
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
-
Non-steroidal Anti-inflammatory agents
Analgesic, Antipyretic
Category C
Ibuprofen's mechanism of action, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition
Ibuprofen is a racemic mixture of [-]R- and [+]S-isomers. In vivo and in vitro studies indicate that the [+]S-isomer is responsible for clinical activity. The [-]R-form, while thought to be pharmacologically inactive, is slowly and incompletely (~60%) interconverted into the active [+]S species in adults. The [-]R-isomer serves as a circulating reservoir to maintain levels of active drug.
Analgesia (Pain)
Administer 400 mg to 800 mg intravenously every 6 hours as necessary. Infusion time must be no less than 30 minutes.
Antipyretic (Fever)
Administer 400 mg intravenously, followed by 400 mg every 4 to 6 hours or 100-200 mg every 4 hours as necessary. Infusion time must be no less than 30 minutes.
Hypersensitivity
Ibuprofen is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to ibuprofen
Asthma and Allergic Reactions
Ibuprofen is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal anaphylactic-like reactions to NSAIDs have been reported in such patients
Coronary Artery Bypass Graft (CABG)
Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery
Cardiovascular Thrombotic Events ,Gastrointestinal Effects: Risk of Ulceration, Bleeding, and Perforation ,Hypertension ,Hepatic Effects ,Congestive Heart Failure and Edema, Renal Effects, Anaphylactoid Reactions, Serious Skin Reactions ,Hematological Effects ,Pre-existing Asthma ,Ophthalmological Effects ,Aseptic Meningitis
Aspirin, Anticoagulants, ACE Inhibitors, Diuretics, Lithium, Methotrexate, H-2 Antagonists,
Pregnancy
Teratogenic effects - Pregnancy Category C prior to 30 weeks gestation; Category D starting at 30 weeks gestation.
Pediatric Use
Safety and effectiveness of Ibuprofen for management of pain and reduction of fever has not been established in pediatric patients below the age of 17 years.
Preparation and Administration
Ibuprofen must be diluted prior to intravenous infusion. Dilute to a final concentration of 4 mg/mL or less. Appropriate diluents include 0.9% Sodium Chloride Injection USP (normal saline), or Lactated Ringers Solution.
• 800 mg dose: Dilute 8 mL of Ibuprofen in no less than 200 mL of diluent.
• 400 mg dose: Dilute 4 mL of Ibuprofen in no less than 100 mL of diluent.
Visually inspect parenteral drug products for particulate matter and discoloration prior to administration, whenever solution and container permit. If visibly opaque particles, discoloration or other foreign particulates are observed, the solution should not be used.
Infusion time must be no less than 30 minutes.
Cardiovascular thrombotic events, Gastrointestinal effects, Hepatic effects, Hypertension, Congestive heart failure and edema, Renal effects, Anaphylactoid reactions, Serious skin reactions,
• Store below 30 C°
• Protect from light and freezing
• Injection 400mg/4ml: boxes of 5 Ampoules
• Injection 800mg/8ml: boxes of 5 Ampoules
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All Rights Reserved.