Indomethacin | Caspian Tamin Pharmaceutical Company

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Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2).
May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. These effects may contribute to its anti-inflammatory activity.

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Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to any component of the product.

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Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to any component of the product.

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• Moderate to severe ankylosing spondylitis.
• Moderate to severe osteoarthritis.
• Acute painful shoulder (bursitis and/or tendinitis).
• Acute gouty arthritis

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• Moderate to severe rheumatoid arthritis including acute flares of chronic disease.
• Moderate to severe ankylosing spondylitis.
• Moderate to severe osteoarthritis.
• Acute painful shoulder (bursitis and/or tendinitis).
• Acute gouty arthritis

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The disposition of indomethacin following intravenous administration (0.2 mg/kg) in pre-term neonates with patent ductus arteriosus has not been extensively evaluated. Even though the plasma half-life of indomethacin was variable among premature infants, it was shown to vary inversely with postnatal age and weight. In one study, of 28 neonates who could be evaluated, the plasma half-life in those less than 7 days old averaged 20 hours (range: 3-60 hours, n=18). In neonates older than 7 days, the mean plasma half-life of indomethacin was 12 hours (range: 4-38 hours, n=10). Grouping the neonates by weight, mean plasma half-life in those weighing less than 1000 g was 21 hours (range: 9-60 hours, n=10); in those neonates weighing more than 1000 g, the mean plasma half-life was 15 hours (range: 3-52 hours, n=18).
Following intravenous administration in adults, indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. Indomethacin undergoes appreciable enterohepatic circulation. The mean plasma half-life of indomethacin is 4.5 hours. In the absence of enterohepatic circulation, it is 90 minutes. Indomethacin has been found to cross the blood-brain barrier and the placenta.
In adults, about 99 percent of indomethacin is bound to protein in plasma over the expected range of therapeutic plasma concentrations. The percent bound in neonates has not been studied. In controlled trials in premature infants, however, no evidence of bilirubin displacement has been observed as evidenced by increased incidence of bilirubin encephalopathy (kernicterus)

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The disposition of indomethacin following intravenous administration (0.2 mg/kg) in pre-term neonates with patent ductus arteriosus has not been extensively evaluated. Even though the plasma half-life of indomethacin was variable among premature infants, it was shown to vary inversely with postnatal age and weight. In one study, of 28 neonates who could be evaluated, the plasma half-life in those less than 7 days old averaged 20 hours (range: 3-60 hours, n=18). In neonates older than 7 days, the mean plasma half-life of indomethacin was 12 hours (range: 4-38 hours, n=10). Grouping the neonates by weight, mean plasma half-life in those weighing less than 1000 g was 21 hours (range: 9-60 hours, n=10); in those neonates weighing more than 1000 g, the mean plasma half-life was 15 hours (range: 3-52 hours, n=18).
Following intravenous administration in adults, indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. Indomethacin undergoes appreciable enterohepatic circulation. The mean plasma half-life of indomethacin is 4.5 hours. In the absence of enterohepatic circulation, it is 90 minutes. Indomethacin has been found to cross the blood-brain barrier and the placenta.
In adults, about 99 percent of indomethacin is bound to protein in plasma over the expected range of therapeutic plasma concentrations. The percent bound in neonates has not been studied. In controlled trials in premature infants, however, no evidence of bilirubin displacement has been observed as evidenced by increased incidence of bilirubin encephalopathy (kernicterus)

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Do not take indomethacin if you:
• are or may be allergic to indomethacin or any ingredients of the medication
• have had an allergic reaction to acetylsalicylic acid (ASA) or other anti-inflammatory medications
• have bleeding in the brain or other bleeding disorders
• have severe liver or kidney disease
• have severe uncontrolled heart failure
• have high blood levels of potassium
• are currently taking other NSAIDs
• are in the third trimester of pregnancy
• have inflammation of the rectum or anus
• have recently had rectal or anal bleeding

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Do not take indomethacin if you:
• are or may be allergic to indomethacin or any ingredients of the medication
• have had an allergic reaction to acetylsalicylic acid (ASA) or other anti-inflammatory medications
• have bleeding in the brain or other bleeding disorders
• have severe liver or kidney disease
• have severe uncontrolled heart failure
• have high blood levels of potassium
• are currently taking other NSAIDs
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• have inflammation of the rectum or anus
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- Blurred vision
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Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2).
May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. These effects may contribute to its anti-inflammatory activity.

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The disposition of indomethacin following intravenous administration (0.2 mg/kg) in pre-term neonates with patent ductus arteriosus has not been extensively evaluated. Even though the plasma half-life of indomethacin was variable among premature infants, it was shown to vary inversely with postnatal age and weight. In one study, of 28 neonates who could be evaluated, the plasma half-life in those less than 7 days old averaged 20 hours (range: 3-60 hours, n=18). In neonates older than 7 days, the mean plasma half-life of indomethacin was 12 hours (range: 4-38 hours, n=10). Grouping the neonates by weight, mean plasma half-life in those weighing less than 1000 g was 21 hours (range: 9-60 hours, n=10); in those neonates weighing more than 1000 g, the mean plasma half-life was 15 hours (range: 3-52 hours, n=18).
Following intravenous administration in adults, indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. Indomethacin undergoes appreciable enterohepatic circulation. The mean plasma half-life of indomethacin is 4.5 hours. In the absence of enterohepatic circulation, it is 90 minutes. Indomethacin has been found to cross the blood-brain barrier and the placenta.
In adults, about 99 percent of indomethacin is bound to protein in plasma over the expected range of therapeutic plasma concentrations. The percent bound in neonates has not been studied. In controlled trials in premature infants, however, no evidence of bilirubin displacement has been observed as evidenced by increased incidence of bilirubin encephalopathy (kernicterus)

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The disposition of indomethacin following intravenous administration (0.2 mg/kg) in pre-term neonates with patent ductus arteriosus has not been extensively evaluated. Even though the plasma half-life of indomethacin was variable among premature infants, it was shown to vary inversely with postnatal age and weight. In one study, of 28 neonates who could be evaluated, the plasma half-life in those less than 7 days old averaged 20 hours (range: 3-60 hours, n=18). In neonates older than 7 days, the mean plasma half-life of indomethacin was 12 hours (range: 4-38 hours, n=10). Grouping the neonates by weight, mean plasma half-life in those weighing less than 1000 g was 21 hours (range: 9-60 hours, n=10); in those neonates weighing more than 1000 g, the mean plasma half-life was 15 hours (range: 3-52 hours, n=18).
Following intravenous administration in adults, indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. Indomethacin undergoes appreciable enterohepatic circulation. The mean plasma half-life of indomethacin is 4.5 hours. In the absence of enterohepatic circulation, it is 90 minutes. Indomethacin has been found to cross the blood-brain barrier and the placenta.
In adults, about 99 percent of indomethacin is bound to protein in plasma over the expected range of therapeutic plasma concentrations. The percent bound in neonates has not been studied. In controlled trials in premature infants, however, no evidence of bilirubin displacement has been observed as evidenced by increased incidence of bilirubin encephalopathy (kernicterus)

) [#title] => [#description] => [#children] =>

The disposition of indomethacin following intravenous administration (0.2 mg/kg) in pre-term neonates with patent ductus arteriosus has not been extensively evaluated. Even though the plasma half-life of indomethacin was variable among premature infants, it was shown to vary inversely with postnatal age and weight. In one study, of 28 neonates who could be evaluated, the plasma half-life in those less than 7 days old averaged 20 hours (range: 3-60 hours, n=18). In neonates older than 7 days, the mean plasma half-life of indomethacin was 12 hours (range: 4-38 hours, n=10). Grouping the neonates by weight, mean plasma half-life in those weighing less than 1000 g was 21 hours (range: 9-60 hours, n=10); in those neonates weighing more than 1000 g, the mean plasma half-life was 15 hours (range: 3-52 hours, n=18).
Following intravenous administration in adults, indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. Indomethacin undergoes appreciable enterohepatic circulation. The mean plasma half-life of indomethacin is 4.5 hours. In the absence of enterohepatic circulation, it is 90 minutes. Indomethacin has been found to cross the blood-brain barrier and the placenta.
In adults, about 99 percent of indomethacin is bound to protein in plasma over the expected range of therapeutic plasma concentrations. The percent bound in neonates has not been studied. In controlled trials in premature infants, however, no evidence of bilirubin displacement has been observed as evidenced by increased incidence of bilirubin encephalopathy (kernicterus)

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The disposition of indomethacin following intravenous administration (0.2 mg/kg) in pre-term neonates with patent ductus arteriosus has not been extensively evaluated. Even though the plasma half-life of indomethacin was variable among premature infants, it was shown to vary inversely with postnatal age and weight. In one study, of 28 neonates who could be evaluated, the plasma half-life in those less than 7 days old averaged 20 hours (range: 3-60 hours, n=18). In neonates older than 7 days, the mean plasma half-life of indomethacin was 12 hours (range: 4-38 hours, n=10). Grouping the neonates by weight, mean plasma half-life in those weighing less than 1000 g was 21 hours (range: 9-60 hours, n=10); in those neonates weighing more than 1000 g, the mean plasma half-life was 15 hours (range: 3-52 hours, n=18).
Following intravenous administration in adults, indomethacin is eliminated via renal excretion, metabolism, and biliary excretion. Indomethacin undergoes appreciable enterohepatic circulation. The mean plasma half-life of indomethacin is 4.5 hours. In the absence of enterohepatic circulation, it is 90 minutes. Indomethacin has been found to cross the blood-brain barrier and the placenta.
In adults, about 99 percent of indomethacin is bound to protein in plasma over the expected range of therapeutic plasma concentrations. The percent bound in neonates has not been studied. In controlled trials in premature infants, however, no evidence of bilirubin displacement has been observed as evidenced by increased incidence of bilirubin encephalopathy (kernicterus)

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• Moderate to severe rheumatoid arthritis including acute flares of chronic disease.
• Moderate to severe ankylosing spondylitis.
• Moderate to severe osteoarthritis.
• Acute painful shoulder (bursitis and/or tendinitis).
• Acute gouty arthritis

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Moderate to severe rheumatoid arthritis including acute flares of chronic disease.
• Moderate to severe ankylosing spondylitis.
• Moderate to severe osteoarthritis.
• Acute painful shoulder (bursitis and/or tendinitis).
• Acute gouty arthritis

) [#title] => [#description] => [#children] =>

• Moderate to severe rheumatoid arthritis including acute flares of chronic disease.
• Moderate to severe ankylosing spondylitis.
• Moderate to severe osteoarthritis.
• Acute painful shoulder (bursitis and/or tendinitis).
• Acute gouty arthritis

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• Moderate to severe rheumatoid arthritis including acute flares of chronic disease.
• Moderate to severe ankylosing spondylitis.
• Moderate to severe osteoarthritis.
• Acute painful shoulder (bursitis and/or tendinitis).
• Acute gouty arthritis

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Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to any component of the product.

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to any component of the product.

) [#title] => [#description] => [#children] =>

Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to any component of the product.

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Treatment of perioperative pain in the setting of coronary artery bypass graft (CABG) surgery; patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs; hypersensitivity to any component of the product.

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Do not take indomethacin if you:
• are or may be allergic to indomethacin or any ingredients of the medication
• have had an allergic reaction to acetylsalicylic acid (ASA) or other anti-inflammatory medications
• have bleeding in the brain or other bleeding disorders
• have severe liver or kidney disease
• have severe uncontrolled heart failure
• have high blood levels of potassium
• are currently taking other NSAIDs
• are in the third trimester of pregnancy
• have inflammation of the rectum or anus
• have recently had rectal or anal bleeding

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Do not take indomethacin if you:
• are or may be allergic to indomethacin or any ingredients of the medication
• have had an allergic reaction to acetylsalicylic acid (ASA) or other anti-inflammatory medications
• have bleeding in the brain or other bleeding disorders
• have severe liver or kidney disease
• have severe uncontrolled heart failure
• have high blood levels of potassium
• are currently taking other NSAIDs
• are in the third trimester of pregnancy
• have inflammation of the rectum or anus
• have recently had rectal or anal bleeding

) [#title] => [#description] => [#children] =>

Do not take indomethacin if you:
• are or may be allergic to indomethacin or any ingredients of the medication
• have had an allergic reaction to acetylsalicylic acid (ASA) or other anti-inflammatory medications
• have bleeding in the brain or other bleeding disorders
• have severe liver or kidney disease
• have severe uncontrolled heart failure
• have high blood levels of potassium
• are currently taking other NSAIDs
• are in the third trimester of pregnancy
• have inflammation of the rectum or anus
• have recently had rectal or anal bleeding

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Do not take indomethacin if you:
• are or may be allergic to indomethacin or any ingredients of the medication
• have had an allergic reaction to acetylsalicylic acid (ASA) or other anti-inflammatory medications
• have bleeding in the brain or other bleeding disorders
• have severe liver or kidney disease
• have severe uncontrolled heart failure
• have high blood levels of potassium
• are currently taking other NSAIDs
• are in the third trimester of pregnancy
• have inflammation of the rectum or anus
• have recently had rectal or anal bleeding

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• ASA (acetylsalicylic acid)
• alcohol
• angiotensin converting enzyme (ACE) inhibitors (e.g., ramipril)
• beta-adrenergic blockers (e.g., metoprolol, atenolol)
• corticosteroids (e.g., prednisone)
• cyclosporine
• digoxin
• diuretics (water pills; e.g., spironolactone, triamterene)
• heparin
• lithium
• methotrexate
• oral hypoglycemics (antidiabetes medications; e.g., glyburide)
• other NSAIDs (e.g., naproxen, diclofenac)
• potassium supplements
• probenecid
• warfarin

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• ASA (acetylsalicylic acid)
• alcohol
• angiotensin converting enzyme (ACE) inhibitors (e.g., ramipril)
• beta-adrenergic blockers (e.g., metoprolol, atenolol)
• corticosteroids (e.g., prednisone)
• cyclosporine
• digoxin
• diuretics (water pills; e.g., spironolactone, triamterene)
• heparin
• lithium
• methotrexate
• oral hypoglycemics (antidiabetes medications; e.g., glyburide)
• other NSAIDs (e.g., naproxen, diclofenac)
• potassium supplements
• probenecid
• warfarin

) [#title] => [#description] => [#children] =>

• ASA (acetylsalicylic acid)
• alcohol
• angiotensin converting enzyme (ACE) inhibitors (e.g., ramipril)
• beta-adrenergic blockers (e.g., metoprolol, atenolol)
• corticosteroids (e.g., prednisone)
• cyclosporine
• digoxin
• diuretics (water pills; e.g., spironolactone, triamterene)
• heparin
• lithium
• methotrexate
• oral hypoglycemics (antidiabetes medications; e.g., glyburide)
• other NSAIDs (e.g., naproxen, diclofenac)
• potassium supplements
• probenecid
• warfarin

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• ASA (acetylsalicylic acid)
• alcohol
• angiotensin converting enzyme (ACE) inhibitors (e.g., ramipril)
• beta-adrenergic blockers (e.g., metoprolol, atenolol)
• corticosteroids (e.g., prednisone)
• cyclosporine
• digoxin
• diuretics (water pills; e.g., spironolactone, triamterene)
• heparin
• lithium
• methotrexate
• oral hypoglycemics (antidiabetes medications; e.g., glyburide)
• other NSAIDs (e.g., naproxen, diclofenac)
• potassium supplements
• probenecid
• warfarin

[#printed] => 1 ) [#title] => [#description] => [#children] => [#printed] => 1 ) [field_side_effects] => Array ( [#type_name] => product [#context] => full [#field_name] => field_side_effects [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 10 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_side_effects [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => - Blurred vision - Confusion - Disturbances of the gut such as nausea vomiting diarrhea or abdominal pain - Dizziness - Facial flushing - Headache - Indigestion or Dyspepsia - Itch - Kidney disorders - Mood changes strange or abnormal thoughts or depression - Sensation of ringing or other noise in the ears - Skin rash - Skin rashes - Swelling of lips tongue or throat [format] => 1 [safe] =>

- Blurred vision
- Confusion
- Disturbances of the gut such as nausea vomiting diarrhea or abdominal pain
- Dizziness
- Facial flushing
- Headache
- Indigestion or Dyspepsia
- Itch
- Kidney disorders
- Mood changes strange or abnormal thoughts or depression
- Sensation of ringing or other noise in the ears
- Skin rash
- Skin rashes
- Swelling of lips tongue or throat

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

- Blurred vision
- Confusion
- Disturbances of the gut such as nausea vomiting diarrhea or abdominal pain
- Dizziness
- Facial flushing
- Headache
- Indigestion or Dyspepsia
- Itch
- Kidney disorders
- Mood changes strange or abnormal thoughts or depression
- Sensation of ringing or other noise in the ears
- Skin rash
- Skin rashes
- Swelling of lips tongue or throat

) [#title] => [#description] => [#children] =>

- Blurred vision
- Confusion
- Disturbances of the gut such as nausea vomiting diarrhea or abdominal pain
- Dizziness
- Facial flushing
- Headache
- Indigestion or Dyspepsia
- Itch
- Kidney disorders
- Mood changes strange or abnormal thoughts or depression
- Sensation of ringing or other noise in the ears
- Skin rash
- Skin rashes
- Swelling of lips tongue or throat

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- Blurred vision
- Confusion
- Disturbances of the gut such as nausea vomiting diarrhea or abdominal pain
- Dizziness
- Facial flushing
- Headache
- Indigestion or Dyspepsia
- Itch
- Kidney disorders
- Mood changes strange or abnormal thoughts or depression
- Sensation of ringing or other noise in the ears
- Skin rash
- Skin rashes
- Swelling of lips tongue or throat

[#printed] => 1 ) [#title] => [#description] => [#children] => [#printed] => 1 ) [field_storage] => Array ( [#type_name] => product [#context] => full [#field_name] => field_storage [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 11 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_storage [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => • Store below 30 C° • Protect from freezing [format] => 1 [safe] =>

• Store below 30 C°
• Protect from freezing

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

• Store below 30 C°
• Protect from freezing

) [#title] => [#description] => [#children] =>

• Store below 30 C°
• Protect from freezing

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_storage [#title] => Storage [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

• Store below 30 C°
• Protect from freezing

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Indomethacin suppository 50 & 100 mg: 10 suppositories/box

[#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] =>

Indomethacin suppository 50 & 100 mg: 10 suppositories/box

) [#title] => [#description] => [#children] =>

Indomethacin suppository 50 & 100 mg: 10 suppositories/box

[#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_packing [#title] => Packing [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] =>

Indomethacin suppository 50 & 100 mg: 10 suppositories/box

[#printed] => 1 ) [#title] => [#description] => [#children] => [#printed] => 1 ) [field_references] => Array ( [#type_name] => product [#context] => full [#field_name] => field_references [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 13 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_references [#weight] => 0 [#theme] => text_formatter_default [#item] => Array ( [value] => [format] => [safe] => [#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => ) [#title] => [#description] => [#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_references [#title] => References [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#printed] => 1 ) [#title] => [#description] => [#printed] => 1 ) [field_pdf] => Array ( [#type_name] => product [#context] => full [#field_name] => field_pdf [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 14 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_pdf [#weight] => 0 [#theme] => filefield_formatter_default [#item] => Array ( [fid] => 254 [uid] => 1 [filename] => indomethacin.pdf [filepath] => sites/default/files/pdf/indomethacin.pdf [filemime] => application/pdf [filesize] => 237051 [status] => 1 [timestamp] => 1329507416 [list] => 1 [data] => [i18nsync] => 1 [nid] => 216 [#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => [#children] => ) [#title] => [#description] => [#children] => [#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_pdf [#title] => PDF [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#children] => [#printed] => 1 ) [#title] => [#description] => [#children] => [#printed] => 1 ) [field_related_products] => Array ( [#type_name] => product [#context] => full [#field_name] => field_related_products [#post_render] => Array ( [0] => content_field_wrapper_post_render ) [#weight] => 15 [field] => Array ( [#description] => [items] => Array ( [0] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_related_products [#weight] => 0 [#theme] => nodereference_formatter_default [#item] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [#delta] => 0 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => ) [1] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_related_products [#weight] => 1 [#theme] => nodereference_formatter_default [#item] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [#delta] => 1 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => ) [2] => Array ( [#formatter] => default [#node] => stdClass Object *RECURSION* [#type_name] => product [#field_name] => field_related_products [#weight] => 2 [#theme] => nodereference_formatter_default [#item] => Array ( [nid] => [i18nsync] => 1 [safe] => Array ( ) [#delta] => 2 ) [#title] => [#description] => [#theme_used] => 1 [#printed] => 1 [#type] => [#value] => [#prefix] => [#suffix] => ) [#title] => [#description] => [#printed] => 1 ) [#single] => 1 [#attributes] => Array ( ) [#required] => [#parents] => Array ( ) [#tree] => [#context] => full [#page] => 1 [#field_name] => field_related_products [#title] => Related Products [#access] => 1 [#label_display] => above [#teaser] => [#node] => stdClass Object *RECURSION* [#type] => content_field [#printed] => 1 ) [#title] => [#description] => [#printed] => 1 ) [#title] => [#description] => [#children] =>

Inhibits synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2).
May inhibit chemotaxis, may alter lymphocyte activity, decrease proinflammatory cytokine activity, and may inhibit neutrophil aggregation. These effects may contribute to its anti-inflammatory activity.

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